Zika Virus Vaccine Development

Zika Virus: Immunity and Vaccine Development

The emergence of Zika virus in the Americas and Caribbean created an urgent need for vaccines to reduce transmission and prevent disease, particularly the devastating neurodevelopmental defects that occur in utero. Rapid advances in Zika immunity and the development of vaccine candidates provide cautious optimism that preventive measures are possible.

Recent Advances in Zika Virus Vaccine Development

Symbiosis Group Figure 1: Three different mechanisms of ADE (Antibody-dependent enhancement): A-receptors on virus particles bound by cross-reactive antibody get conformational change in structure that results in high affinity with the corresponding receptor on the host cell membrane. The corresponding receptor was not able to recognize the viral receptor before this conformational change. BThe...

Development of a Zika vaccine.

Considerations for Developing a Zika Virus Vaccine.

Current prevention strategies fo­ cus on mosquito control, protec­ tion of the blood supply, barrier protection during sex, and other forms of contraception. When this explosive epidemic abates, Zika vi­ rus could remain endemic in many countries, where the risk to preg­ nant women, the general public, and travelers will persist. There­ fore, a safe and effective vaccine is essential. Developme...

Zika Virus: Diagnosis, Therapeutics, and Vaccine.

The current explosive epidemic of Zika virus in South and Central America, as well as the Caribbean, poses a global public health emergency. Here we comment on the challenges on development of better diagnosis and potential therapeutics and vaccine for Zika virus.